Stem Cells and Disease Modeling

The Stem Cell and Disease Modeling research team (SCDM) builds on long term experience with human pluripotent stem cells, their cultivation and their differentiation.

The current focus of the team aims at the use of human pluripotent stem cells to model human diseases with special foccus on the role of tissue specific progenitors/stem cells on the development of the disease. We foccus on uncovering pathologies in pathways leading to change of cell fate, resulting in tissue failure. We further seek novel strategies to ameliorate the pathological effect on the progenitor/stem cell fate hange. We mostly foccus on processes involven in development of cardiomyopathy and heart failure in monogenic genetic diseases, such as Duchenne Muscular Dystrophy, Catecholinergic Polymorphic Ventricular Tachycardia and also on processes involved in pathological changes of hematpoietic differentiation in genetic diseasaes, such as Nijmegen Breakage Syndrome. Our group uses reprogrammed human patient cells, as well as human embryonic stem cells with edited genome, to create models of monogenic diseases involving cardiomyopathy and pathological hematopoiesis „on the dish“. The team also complements stem cell based modeling with the analysis of both animal models and human patient samples. The SCDM team has also developed novel technology to analyze mechanoelectrical coupling in stem cell derived patients, specifically cardiac syn­cytium based on atomic force microscope.