MUDr. Katarína Doležalová
Ph.D. Student
Interventional Cardiac Electrophysiology
Our team investigates fundamental mechanisms and translates findings from bench to bedside, combining preclinical models with clinical insight.
Researcher at ICRC with focus on translational medicine. Combines preclinical insights with clinical practice across cardiology, neurology, and oncology programs.
Currently leads / contributes to interdisciplinary projects bridging molecular biology, imaging, and patient care at St. Anne's University Hospital Brno.
Research Group
- Team size
- Team size: 12 Researchers
- Place
- Place: Building C2, 2nd Floor
- Collaborates with
- Collaborates with Mayo Clinic, USA
Head of Research Group
- doc. MUDr. Zdeněk Stárek, Ph.D.
Members
MUDr. Ing. Richard Ředina
Ph.D. Student
Ing. Jakub Hejč, Ph.D.
Senior Researcher
MVDr. Eva Odehnalová
Senior Researcher
Bc. Matthew Humlíček
Research Technician
Bc. Marek Babinec
Research Technician
MUDr. Martin Pešl, Ph.D.
Postdoctoral Researcher
MUDr. Filip Souček
Postdoctoral Researcher
Tomasz Jadczyk, MD
Postdoctoral Researcher
Ing. Alice Vybíralová
Research Coordinator
doc. MUDr. Zdeněk Stárek, Ph.D.
Senior Research Team Leader
Ing. Martin Mátych
Research Technician Specialist
Team Assistant
Ing. Alice Vybíralová
Administrative Support
Main Objectives
- Development of new ablation tools – catheters and generators of ablation energy and their testing in an animal model.
- Clinical studies of ablation strategies for cardiac arrhythmias and procedures to increase their safety.
Research focus
We specialize in clinical and preclinical research in the field of interventional cardiology with a focus on effective and safe catheterization treatment of arrhythmias.
In cooperation with commercial and academic partners, we are dedicated to the development of new technologies for catheterization ablation of cardiac arrhythmias. We help advance knowledge in the field of 3D imaging of cardiac structures, modalities for cardiac electrophysiology, and regeneration strategies using stem cells.
We have our own development team, which provides support in data analysis, automatic processing of biological signals, and the use of machine learning models in cardiology.
Our long-term achievements include patented technology for ablation by the pulsed electric field (Patent No. 308415) and together with clinical verification of catheters for this technology, on which we cooperate with the Brno University of Technology.
With researchers from Mayo Clinic, USA, our team was involved in the development of catheters for epicardial stimulation, defibrillation, and ablation of cardiac tissue in chronic experiments (Patent No. 11020589).
Technological equipment
- STEREOTAXIS EPOCH™ – catheter magnetic navigation system – clinical research
- EnSite Precision, EnSite X, and Carto 3 – 3D electroanatomical mapping system
- Catheterization ablation systems – RFA radiofrequency ablation, PEF pulse-field ablation, cryoablation, laser ablation.
- Implantation hall with complete equipment.
- Fully equipped electrophysiological hall with new technologies.
Selected Results
- Selected clinical trials and publications
- Cabana 2015-2017 “Catheter Ablation vs Anti-arrhythmic Drug Therapy for Atrial Fibrillation” NCT00911508
- Eliminate AF 2017-2018 NCT02942576 Periprocedural edoxaban anticoagulation in RF ablation
- DIAMOND AF I-II 2017-2019 NCT03643224/NCT03334630/ NCT02821351 testing of new studies following ICE animal experiments
- WAVE-MAP AF 2020-2021 High-Density (HD) Wave Mapping in patients with Atrial Fibrillation NCT03882021I don’t know.
- Mark DB, Anstrom KJ, Sheng S, Piccini JP, Baloch KN, Monahan KH, Daniels MR, Bahnson TD, Poole JE, Rosenberg Y, Lee KL, Packer DL; CABANA Investigators. Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial. JAMA. 2019 Apr 2;321(13):1275-1285. doi: 10.1001/jama.2019.0692.
- Starek Z, Lehar F, Jez J, Scurek M, Wolf J, Kulik T, Zbankova A, Novak M. Three-dimensional rotational angiography of the left atrium and the oesophagus: the short-term mobility of the oesophagus and the stability of the fused three-purpose model of the left atrium dimensionand the oesophagus catheter ablation for atrial fibrillation. Europace. 2017, 19(8), 1310-1316. ISSN 1099-5129.
- Caluori G, Odehnalova E, Jadczyk T, Pesl M, Pavlova I, Valikova L, Holzinger S, Novotna V, Rotrekl V, Hampl A, Crha M, Cervinka D, Starek Z. AC Pulsed Field Ablation Is Feasible and Safe in Atrial and Ventricular Settings: A Proof-of-Concept Chronic Animal Study. Front Bioeng Biotechnol. 2020 Dec 3;8:552357. doi: 10.3389/fbioe.2020.552357.
- Patent: AC electroporation generator. 308415 Starek Z, Pesl M, Caluori G, Cervnika D, Martis J, Novotna V @ Patent: Multi-electrode epicardial pacing, US Patent office 10279170: Syed FF, Bruce ChJ, DeSimone ChV, Friedman PA, Asirvatham SJ, Kara T, Leiveber P, Novak M, Starek Z, Wolf J
- Utility model 2019-36328 33133 Electroporation or for cardiac tissue ablation @ Utility model 2019-36329 33134 High voltage AC power supply for electroporation
