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Stroke

Our team investigates fundamental mechanisms and translates findings from bench to bedside, combining preclinical models with clinical insight.

Researcher at ICRC with focus on translational medicine. Combines preclinical insights with clinical practice across cardiology, neurology, and oncology programs.

Currently leads / contributes to interdisciplinary projects bridging molecular biology, imaging, and patient care at St. Anne's University Hospital Brno.

Research Group

Team size
Team size: 52 Researchers
Place
Place: Building A1, 3rd Floor
Collaborates with
Collaborates with Mayo Clinic, USA

Head of Research Group

prof. MUDr. Robert Mikulík, Ph.D.
prof. MUDr. Robert Mikulík, Ph.D.
prof. MUDr. Robert Mikulík, Ph.D.

Members

Mgr. Patrícia Kittová

Mgr. Patrícia Kittová

Junior Researcher

Mgr. Michaela Pešková

Ph.D. Student

MVDr. Peter Scheer, Ph.D.

MVDr. Peter Scheer, Ph.D.

Senior Researcher

Geraldo De Albuquerque Maranhao Neto, Ph.D.

Geraldo De Albuquerque Maranhao Neto, Ph.D.

Senior Researcher

Mgr. Zuzana Mezerová

Study Coordinator

Bc. Ivana Heib, MN

Bc. Ivana Heib, MN

Study Coordinator

Kristýna Znamenáčková

Kristýna Znamenáčková

Study Coordinator

Lenka Bártová

Lenka Bártová

Study Coordinator

Mgr. Helena Trubačová

Mgr. Helena Trubačová

Study Coordinator

Jana Lichá

Study Coordinator

Karin Kunzová

Karin Kunzová

Study Coordinator

Iveta Janebová

Iveta Janebová

Study Coordinator

Filip Pergler

Filip Pergler

Study Coordinator

Bc. Zuzana Bubáková, MBA, LL.M.

Bc. Zuzana Bubáková, MBA, LL.M.

Study Coordinator

Mgr. Zuzana Kašpárka

Study Coordinator

Nadežda Dujavová

Nadežda Dujavová

Study Coordinator

Mgr. Martina Slachová

Mgr. Martina Slachová

Research Assistant

Tereza Krejčiříková

Tereza Krejčiříková

Research Assistant

Bc. Klára Kuříková

Bc. Klára Kuříková

Research Assistant

Darja Urbánková

Darja Urbánková

Research Technician

Františka Hamáková

Františka Hamáková

Research Technician

Mgr. Nikola Neumeisterová

Mgr. Nikola Neumeisterová

Research Technician

MUDr. Michal Haršány, Ph.D.

MUDr. Michal Haršány, Ph.D.

Postdoctoral Researcher

doc. MUDr. Ondřej Volný, Ph.D.

Postdoctoral Researcher

MVDr. Jana Hložková, Ph.D.

MVDr. Jana Hložková, Ph.D.

Postdoctoral Researcher

MUDr. Ing. Mgr. Petra Šedová, Ph.D.

MUDr. Ing. Mgr. Petra Šedová, Ph.D.

Postdoctoral Researcher

Mgr. Sandra Thalerová, Ph.D.

Postdoctoral Researcher, Principal Investigator junior, Research Specialist

MVDr. Jana Doležalová, Ph.D.

MVDr. Jana Doležalová, Ph.D.

Postdoctoral Researcher

doc. MVDr. Adam Novobilský, Ph.D.

Postdoctoral Researcher

Bc. Eva Bendová

Research Nurse

Mgr. Petra Hrstková

konzultant

Ing. Hana Maršálková

Ing. Hana Maršálková

konzultant

Ing. MgA. Veronika Svobodová

Ing. MgA. Veronika Svobodová

Research Manager

Ing. Lenka Hýblová, DiS.

Research Manager

Mgr. Miroslav Vařecha, Ph.D.

Mgr. Miroslav Vařecha, Ph.D.

Senior Postdoctoral Researcher

Mgr. Martin Páleník

IT Specialist

Mgr. Bc. Lucie Pražáková

Mgr. Bc. Lucie Pražáková

Research Coordinator

Mgr. Jana Faturová

Research Coordinator

MUDr. Martin Šrámek

Senior Study Coordinator of Clinical Studies

MUDr. Monika Veclová

MUDr. Monika Veclová

Senior Study Coordinator of Clinical Studies

prof. MUDr. Robert Mikulík, Ph.D.

prof. MUDr. Robert Mikulík, Ph.D.

Senior Research Specialist, Senior Research Team Leader

doc. MUDr. Aleš Hejčl, Ph.D.

doc. MUDr. Aleš Hejčl, Ph.D.

Senior Research Specialist

MUDr. Ivan Kantorek

MUDr. Ivan Kantorek

Senior Research Specialist

MUDr. Jakub Štefela

MUDr. Jakub Štefela

Research Specialist

Ing. Marie Švaňhalová, Ph.D.

Research Specialist

MVDr. Eliška Brhelová

Research Specialist

Ahmet Davut Aksu, MSc

Research Specialist

Mgr. Kristýna Dušková

Pedagogický konzultant

Mgr. Kristýna Douchová

Pedagogický konzultant

Ing. Ondřej Steffl

Ing. Ondřej Steffl

Senior IT Specialist

Ing. Pavla Šafránková, DiS.

Research Technician Specialist

Team Assistant

Mgr. Marcela Čechová

Administrative Support

Mgr. Marcela Čechová

Main Objectives

  1. Research on implementation of evidence-based treatments.
  2. Development of in vitro and animal model for stroke to test new diagnostics (e.g. basic thrombus imaging) and therapeutic strategies (e.g. new recanalizaton methods).
  3. Identification of beter stroke awareness methods including program on stroke awareness in children.

Research focus

Research actvites of the Stroke Research Group (STR) include development and implementation of innovative methods for the evaluation, treatment, and prevention of acute ischemic stroke. Research portfolio is designed across translational axis from basic science to clinical research and implementation research. The emphasis is on a translational approach so that knowledge gained through basic research is applied and tested in clinical practice and then translated into health care system and population.

European Stroke Organisation, Switzerland

ANGELS Initative, The world-wide stroke support project, Germany

University of Calgary, Canada

Network of Stroke Centres in Central and Eastern Europe

Simulation training and methodology- is intended for stroke teams and professionals in stroke.

System Engineering/Software Developing and data management.

Preclinical Research: highly sophisticated in vitro flow models and small animal models of stroke.

Web-based platform for education of children and lay public in Stroke.

Coordination of clinical trials.

Technological equipment

  • Fully equipped Stroke Unit with neuroimaging machines.
  • The Laboratory of Nanopharmacology NAPHARM is a joint workplace of the Veterinary Research Institute and FNUSA-ICR.
  • IT infrastructure for medical databases and research.

Selected Results

  • The Stroke Research Group has developed innovative platorms for evaluating stroke care quality data (RES-Q), as well as for providing education and testing to school children about stroke (HOBIT). Currently, an advanced medical imaging database for stroke, as well as other registry based research initatives.
  • Highly sophisticated in vitro 3D flow models for testing new recanalization methods.
  • HART, R., SHARMA, M., MUNDL, H., KASNER, S., BANGDIWALA, S., BERKOWITZ, S., SWAMINATHAN, B., LAVADOS, P., WANG, Y., WANG, Y., DAVALOS, A., SHAMALOV, N., MIKULÍK, R. et al. Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source. New England Journal of Medicine. 2018, 378(23), 2191-2201. ISSN 0028-4793. IF 70.670.
  • MENON, B., AL-AJLAN, F., NAJM, M., PUIG, J., CASTELLANOS, M., DOWLATSHAHI, D., CALLEJA, A., SOHN, S., AHN, S., POPPE, A., MIKULÍK, R. et al. Association of Clinical, Imaging, and Thrombus Characteristics with Recanalization of Visible Intracranial Occlusion in Patients with Acute Ischemic Stroke. JAMA. 2018, 320(10), 1017-1026. ISSN 0098-7484. IF 51.273.
  • ALEXANDROV, AV., KOHRMANN, M., SOINNE, L., TSIVGOULIS, G., BARRETO, AD., DEMCHUK, AM., SHARMA, VK., MIKULÍK, R. et al. Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial. Lancet Neurology. 2019, 18(4), 338-347. ISSN 1474-4422. IF 28.755.
  • Mikulík R, Eckstein J, Pearce LA, Mundl H, Rudilosso S, Olavarría VV, Shoamanesh A, Chamorro Á, Martí-Fàbregas J, Veltkamp R, Öztürk Ş, Tatlisumak T, Peacock WF, Berkowitz SD, Connolly SJ, Hart RG. Frequency and Predictors of Major Bleeding in Patients With Embolic Strokes of Undetermined Source: NAVIGATE-ESUS Trial. Stroke 2020, July; 51:2139–2147.